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The hypopigmentation associated with PIH that develops after injury, burn, or other inflammatory condition may be permanent if the melanocytes in the area have been severely damaged or destroyed

PMID: 7987362

Elevations of the intermediate S-Adenosylhomocysteine (SAH) lead to a feed back inhibition of the function of the cycle and also a reduction in the transsulfuration pathway leading to a deficiency in the production of cysteine and glutathione (James)

doi:10.1016/j.neulet.2020.135058 125

Blood pressure improvements were observed across prespecified subgroups including participants with and without baseline hypertension